Ocular Surface as Barrier of Innate Immunity

Bolaños-Jiménez, Rodrigo; Navas, Alejandro; López-Lizárraga , Erika Paulina; Ribot , Francesc March de; Peña , Alexandra; Graue-Hernández , Enrique O; Garfias , Yonathan

Ocular Surface as Barrier of Innate Immunity

Rodrigo Bolaños-Jiménez^{*, 1, 2}, Alejandro Navas^{1, 3}, Erika Paulina López-Lizárraga ³, Francesc March de Ribot ⁴, Alexandra Peña ², Enrique O Graue-Hernández ^{1, 3}, Yonathan Garfias ^{1, 5}

¹ Research Unit, Institute of Ophthalmology, Conde de Valenciana Foundation, Chimalpopoca 14, Obrera, CP 06800, Mexico City, México

² Ophthalmology Department, Regional Hospital, Adolfo López Mateos, ISSSTE, México City, México

³ Department of Cataract and refractive surgery, Institute of Ophthalmology, Conde de Valenciana Foundation, Mexico City, México

⁴ Department of Retina, Institute of Ophthalmology, Conde de Valenciana Foundation, Mexico City, México

⁵ Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autónoma de México, 04510. Mexico City, Mexico

Article Information

Identifiers and Pagination:

Year: 2015
Volume: 9
First Page: 49
Last Page: 55
Publisher ID: TOOPHTJ-9-49
DOI: 10.2174/1874364101509010049

Article History:

Received Date: 18/11/2014
Revision Received Date: 6/4/2015
Acceptance Date: 13/4/2015
Electronic publication date: 15/5/2015
Collection year: 2015

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© Bolaños-Jiménez et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Research Unit, Institute of Ophthalmology Chimalpopoca 14, Obrera, 06800 Mexico City, Mexico; Tel: +52(55) 54421700, Ext. 3212; Fax: +52(55) 54421700, Ext. 3206; E-mail: rodrigoboji88@gmail.com

Sight is one of the most important senses that human beings possess. The ocular system is a complex structure equipped with mechanisms that prevent or limit damage caused by physical, chemical, infectious and environmental factors. These mechanisms include a series of anatomical, cellular and humoral factors that have been a matter of study. The cornea is not only the most powerful and important lens of the optical system, but also, it has been involved in many other physiological and pathological processes apart from its refractive nature; the morphological and histological properties of the cornea have been thoroughly studied for the last fifty years; drawing attention in its molecular characteristics of immune response. This paper will review the anatomical and physiological aspects of the cornea, conjunctiva and lacrimal apparatus, as well as the innate immunity at the ocular surface.

Keywords: Cornea, innate immunity, mucins, neuropeptides, ocular surface, pattern recognition receptors.

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RESEARCH ARTICLE

Ocular Surface as Barrier of Innate Immunity

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