Pathophysiology of Keratoconus: What Do We Know Today
Uri Soiberman, James W. Foster, Albert S. Jun, Shukti Chakravarti*
Identifiers and Pagination:Year: 2017
Issue: Suppl-1, M9
First Page: 252
Last Page: 261
Publisher ID: TOOPHTJ-11-252
Article History:Received Date: 18/02/2017
Revision Received Date: 01/04/2017
Acceptance Date: 14/06/2017
Electronic publication date: 31/07/2017
Collection year: 2017
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological studies of the keratoconic cornea, relate these early studies with current findings from proteomic, biochemical and cell culture studies and to postulate possible pathogenic pathways.