REVIEW ARTICLE
A Single Drop in the Eye – Effects on the Whole Body?
Anu Vaajanen1, 2, *, Heikki Vapaatalo3
Article Information
Identifiers and Pagination:
Year: 2017Volume: 11
First Page: 305
Last Page: 314
Publisher ID: TOOPHTJ-11-305
DOI: 10.2174/1874364101711010305
Article History:
Received Date: 16/05/2017Revision Received Date: 12/09/2017
Acceptance Date: 16/10/2017
Electronic publication date: 31/10/2017
Collection year: 2017

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Introduction:
Although the local adverse effects of ophthalmic drugs, including allergic reactions, are well recognized, less is known about the systemic side- effects of eye drops, especially during pregnancy, breast-feeding and early childhood. Ophthalmologists should also be aware of unusual, in some cases even life-threatening, effects of commonly used eye drops.
Conclusion:
This brief review outlines the routes of systemic absorption and the kinetics of active components present in eye drops, and identifies the clinically relevant systemic adverse effects.