A Single Drop in the Eye – Effects on the Whole Body?
Anu Vaajanen1, 2, *, Heikki Vapaatalo3
Identifiers and Pagination:Year: 2017
First Page: 305
Last Page: 314
Publisher ID: TOOPHTJ-11-305
Article History:Received Date: 16/05/2017
Revision Received Date: 12/09/2017
Acceptance Date: 16/10/2017
Electronic publication date: 31/10/2017
Collection year: 2017
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Although the local adverse effects of ophthalmic drugs, including allergic reactions, are well recognized, less is known about the systemic side- effects of eye drops, especially during pregnancy, breast-feeding and early childhood. Ophthalmologists should also be aware of unusual, in some cases even life-threatening, effects of commonly used eye drops.
This brief review outlines the routes of systemic absorption and the kinetics of active components present in eye drops, and identifies the clinically relevant systemic adverse effects.