Unilateral Adult Xanthogranulomatous Infiltration of the Conjunctiva, Limbus and Sclera Leading to a Combined Ophthalmic Artery and Central Retinal Vein Occlusion

Burak Unlu1, Ziya Ayhan1, Banu Lebe2, Suleyman Men3, Ismet Durak1, Ali Osman Saatci1, *
1 Department of Ophthalmology, Dokuz Eylul University, İzmir, Turkey
2 Department of Pathology, Dokuz Eylul University, İzmir, Turkey
3 Department of Radiology, Dokuz Eylul University, İzmir, Turkey

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© 2017 Unlu et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Ophthalmology, Dokuz Eylul University, Mustafa Kemal Sahil Bulvarı No:73, A Blok Daire:9, Narlidere, İzmir, 35320, Turkey; Tel: +905055251600; E-mail:



To describe the features of a female patient with a biopsy-proven xanthogranulomatous infiltration of the conjunctiva, limbus and sclera who had an exudative retinal detachment, combined ophthalmic artery and central retinal vein occlusion unilaterally.


A-53-year old otherwise healthy woman presenting with a painful visual loss in her right eye underwent an ophthalmic examination, meticulous systemic work-up and histopathologic assessment.


Ophthalmic examination revealed multiple subconjunctival masses, upper limbal infiltrations, trace cells in the anterior chamber, pale looking posterior fundus, 360 degree scattered retinal hemorrhages and marked exudative retinal detachment in her right eye. Left eye was completely normal.A biopsy taken from one of the subconjunctival masses demonstrated a diffuse infiltration of the histiocytes and this was interpreted as a xanthogranulomatous infiltration with the help of immunohistochemical staining techniques.


Present case is the only reported adult case with xanthogranulomatous-like infiltration of the eyeball featuring both anterior and posterior segment involvement without any concomitant major systemic disturbances.

Keywords: Conjunctiva, Exudative retinal detachment, Limbus, Retinal artery occlusion, Retinal vein occlusion, Sclera, Xanthogranulomatous infiltration.