RESEARCH ARTICLE


Ocular Manifestations in Patients with Coronavirus Disease 2019 (COVID-19): A Real World Multicenter Observational Study in Egypt



Raouf Gaber1, Sherief Abd-Elsalam2, *, Mai Khalaf2, Eslam Saber Esmail2, Ossama Ashraf Ahmed3, Hatem Fawzy4, Shaimaa Soliman5, Kamal Okasha6, Doaa El Amrousy7, Ahmed M. Ghoneim1
1 Department of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, Egypt
2 Department of Tropical Medicine and Infectious diseases, Faculty of Medicine, Tanta University, Tanta, Egypt
3 Internal Medicine, Faculty of Medicine, Ain-Shams University, Cairo, Egypt
4 Department of Ophthalmology, Faculty of Medicine, Ain-Shams University, Cairo, Egypt
5 Public health and Community Medicine, Menoufia University, Menoufia, Egypt
6 Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt
7 Department of Pediatric, Faculty of Medicine, Tanta University, Tanta, Egypt


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Creative Commons License
© 2022 Gaber et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University., El-Giash Street 31527, Tanta, Egypt; Tel: +2-01224608774; E-mail: sherif.abdelbaky@med.tanta.edu.eg


Abstract

Background:

The aim of the work was to evaluate the ocular manifestations in the patients with COVID-19 and its role in the prediction of the course and the outcome of the disease.

Methods:

This retrospective study was conducted at two tertiary referral COVID-19 isolation hospitals in two major university hospitals in Egypt. Two hundred and twenty-eight patients were enrolled in the study. The medical records of patients who had clinically confirmed COVID-19 between 1/5/2020 to 15/7/2020 were retrospectively reviewed. Data were collected from patient charts, including age, sex, accommodation, ocular manifestations, fever, headache, cough, dyspnea, anosmia, cyanosis, abdominal pain, anorexia, liver, kidney, cardiac manifestations, CT, X-ray finding, blood tests, and outcome of the disease.

Results:

Thirty-four patients with ocular manifestation were finally enrolled in the study with a mean age of 42.1 years; 20 patients (58.8%) were men. The incidence of ocular manifestation was 14.9% (34/228). All patients with ocular manifestations had conjunctivitis (redness, epiphora, foreign body sensation), which had been treated and resolved completely within 10 days in all patients without any permanent ocular damage. There was a trend between the presence of ocular manifestations and the associated milder disease course, although this trend was not statistically significant.

Conclusion:

Ophthalmic manifestation is common in patients with COVID-19 and it occurs more frequently in patients with mild to moderate form of COVID-19, but it could not predict the patient’s mortality.

Keywords: Conjunctivitis, Eye, Pandemic, SARS, SARS-CoV-2, Viruses.