A Novel approach for Corneal Remodeling of Laser Asymmetric Keratectomy with Collagen Cross Linking in Patients with Keratoconus Suspect

Ji Sang Min1, Dongcho Lee2, SeongSu Lee3, Pyung Moo Min4, *
1 Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea
2 Department of Ophthalmology, Yeongdong Joeun Eye Clinic, Dankook University College of Medicine, 33 Juongang-ro Yeongdong up, Yeongdong 29145, Republic of Korea
3 Lee Seong Su Eye Clinic, 863 Jinju-Daero, Jinju 52716, Republic of Korea
4 Department of Ophthalmology, Woori Eye Clinic, Yonsei University College of Medicine, Daeduk Daero 219 (Dunsan-dong), Seo-gu, Daejon 35229, Republic of Korea

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© 2024 The Author(s). Published by Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Ophthalmology, Woori Eye Clinic, Yonsei University College of Medicine, Daeduk Daero 219 (Dunsan-dong), Seo-gu, Daejon 35229, South Korea; Tel: 82-42-476-1675; Fax: 82-42-476-1670; E-mail:



True Keratoconus Suspect (KCS) is an absolute contraindication to LASIK or Photorefractive Keratectomy (PRK) due to postoperative ectasia.


To evaluate the effectiveness of laser asymmetric keratectomy with collagen cross-linking (L-LAK-CXL) in myopic patients with suspected keratoconus (KCS).


This study included 40–44-year-old four myopic (-2.50 to -5.50 D) patients (4 eyes), of KCS with focal corneal steepening over +47.0 D and peripheral asymmetric corneal thickness. L-LAK-CXL was performed for both original ablation of refractive errors and crescentic customized ablation of the thicker peripheral cornea selectively and myopic changes due to the ablation of the peripheral thicker cornea simultaneously, followed by CXL without the epithelium. We compared preoperative and postoperative ocular findings, including corneal symmetry (total differences of the corneal thickness in four directions (SUM) and decentration of the thinnest point (DISTANCE)) and tear break-out time (TBUT).


From preoperative to postoperative, spherical equivalent (D, average) decreased from -3.38 to -0.34, uncorrected distance visual acuity (LogMAR) increased from 0.53 to 0.00, and Kmax (average D) had decreased from +48.3 to +43.95, central pachymetry (CP, µm, average) decreased from 574 to 511. Postoperative corneal symmetry increased markedly owing to decreased SUM and DISTANCE scores. TBUT increased over 15 s postoperatively. No post-operative corneal ectasia was observed.


L-LAK-CXL improved corneal symmetry in myopic patients with KCS by reducing SUM, decreasing DISTANCE and Kmax, increasing TBUT, and demonstrating good postoperative visual outcomes.

Keywords: Corneal remodeling technique, Keratoconus suspect, L-LAK, Myopia, Collagen cross-linking, Corneal symmetry, Customization ablation, Focal corneal steepening.