A Clinical Study Evaluating How Delefilcon A Contact Lenses Perform in Satisfied Senofilcon A Contact Lens Wearers

To investigate whether satisfied daily disposable Contact Lens (CL) wearers can switch CL brands and remain satisfied as CL wearers.

This 2-month, 4-visit switch study (NCT06847230) recruited 18- to 40-year-old subjects who were currently satisfied Acuvue® Oasys MAX (MAX; senofilcon A) CL wearers (CLDEQ-8 score <12). Visits 1 and 2 confirmed that subjects had well-fit MAX CLs. Subjects were then refitted into Dailies Total1® (DT1; delefilcon A) CLs and were asked to start wearing them at Visit 3. Subjects then returned 1 month later to have their DT1 CLs evaluated with the CLDEQ-8, Visual Analog Scales (VAS), and the Impact of Dry Eye on Everyday Life (IDEEL) Quality Of Life (QoL) domains.

This study enrolled 36 CL wearers, with a median (interquartile range) age of 30.5 (11.0) years (69.4% female). After switching to DT1, the study found a median CLDEQ-8 score of 8.5 (10.5) (asymptomatic level).

Median IDEEL questionnaire scores while wearing DT1 were good, with daily activities at 97.8 (8.9) units, feelings at 97.9 (7.3) units, and work scores at 100 (10) units. Subjects likewise rated their end-of-day eye comfort (35.0 [32.5] units), eye dryness (25.0 [58.0] units), and clarity of vision (44.5 [18.0] units) as good with a ±50 VAS (positive = comfortable; negative = uncomfortable).

This study found that most subjects were able to remain satisfied CL wearers and had a positive CL wearing experience after switching CL brands, suggesting that clinicians can have confidence when switching patients from senofilcon A to delefilcon A daily disposable CLs.