Regression of Urrets-Zavalia Syndrome After Deep Lamellar Keratoplasty for Keratoconus: A Case Study

Leopoldo Spadea*, Mariangela Viola, Giovanna Viola
Eye Clinic, San Salvatore Hospital, Surgical Science Department, University of L'Aquila, L’Aquila, Italy

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© Spadea et al.; Licensee Bentham Open.

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* Address correspondence to this author at the Via Benozzo Gozzoli 34, 00142 Rome, Italy; Tel: +39/0862/319671; Fax: +39/0862/319672; E-mail:


We report a case of pharmacologic regression of Urrets-Zavalia syndrome, following deep lamellar keratoplasty for severe keratoconus. Sympatholytic and parasympathomimetic drops were administered and a progressive reduction of mydriasis and restoring of pupillary kinetics were observed. Four years after surgery, it was resulting in only slight residual anisocoria.

Keywords: Dapiprazole, DLK, keratoconus, pilocarpine, Urrets-Zavalia syndrome.