Additive Effect of Brinzolamide on Diurnal Changes in Intraocular Pressure in Latanoprost-treated Eyes

Keitetsu Abe1, Kenji Kashiwagi2, *
1 Department of Ophthalmology, Yamanashi Prefectural Central Hospital, Kofu, Yamanashi, Japan
2 Department of Community and Family Medicine, and Department of Ophthalmology Interdisciplinary School of Medi-cine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan

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© Abe and Kashiwagi; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Ophthalmology, University of Yamanashi Faculty of Medicine, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan; Tel: 81-552-73-9657; Fax: 81-552-73-6757;


To investigate the effect of brinzolamide on diurnal fluctuations in the intraocular pressure (IOP) in patients on latanoprost ophthalmic solution prospectively was aimed. Eleven patients with primary open angle glaucoma were enrolled in this study. The subjects were admitted to the hospital and had their IOPs measured over 24 hours (10 AM, noon, 2 PM, 4 PM, 6 PM, 8 PM, 10 PM, midnight, 3 AM, 6 AM, and 8AM). After topical administration of brinzolamide twice daily for 4-8 weeks for one eye, they were readmitted and again had their IOPs measured in the same manner as during the previous admission. The additional administration of brinzolamide significantly reduced IOP by 9.7±4.5% during 24-hour, 9.5±4.7% during daytime, and 10.3±5.6% during nighttime, respectively. Brinzolamide exerts additive effects over 24 hours in reducing IOP in patients with glaucoma who are receiving latanoprost ophthalmic solution.

Keywords: Brinzolamide, additive effect, diurnal IOP changes, latanoprost, intraocular pressure.