Additional Applications of Corneal Cross Linking

Vassilios Kozobolis*, Georgios Labiris, Maria Gkika , Haris Sideroudi
Eye Institute of Thrace (EIT), Democritus University, Alexandroupolis, Greece

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© Kozobolis et al.; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Eye Institute of Thrace, Democritus University, Department of Medicine, Alexandroupolis, Greece; Tel: +302551030990; Fax: 302551039891; E-mail:


Corneal collagen cross-linking (CxL) is a prevalent surgical method for the management of keratoconus. However, literature suggests that, further to keratoconus, CxL has a beneficial impact on a series of corneal related diseases and states.

This article attempts to provide a contemporary review for all additional applications of CxL. Specifically, it outlines the most recent studies that demonstrate the beneficial impact of CxL for iatrogenic ectasias, pellucid marginal degeneration, infectious keratitis, bullous keratitopathy, and for ulcerative keratitis.

The outcome of this review indicates that CxL could serve as a primary or adjuvant therapeutic modality for all aforementioned corneal-related pathologic states.

Keywords: Corneal collagen cross-linking, review, iatrogenic ectasias, pellucid marginal degeneration, bullous keratopathy, infectious keratitis.