Late Onset Retinoblastoma Presenting with Vitreous Haemorrhage

Mette Bagger*, 1 , Jan Ulrik Prause 2, Steffen Heegaard1 , 2, 3, Steen Fiil Urbak 4, Torsten Degn 5, Jens Folke Kiilgaard 1 , 3
1 Department of Ophthalmology, Glostrup University Hospital, Glostrup, Denmark
2 Section of Eye Pathology, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark
3 Department of Neurology, Psychiatry and Sensory Sciences, University of Copenhagen, Copenhagen, Denmark
4 Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark
5 Department of Ophthalmology, Odense University Hospital, Odense, Denmark

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© Bagger et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Ophthalmology, Glostrup UniversityHospital, Glostrup, Denmark; Tel: +4527383169; E-mail:


Our work describes the management of young patients who presents with vitreous haemorrhage. It is important to note that the causes differ significantly from adults with vitreous haemorrhage.

A 16-year old patient presented with vitreous haemorrhage. B-scan ultrasonography showed hypodense elements in the retina. A vascularized gelatinous mass was revealed after vitrectomy. Later the patient developed white cysts in the anterior chamber and histological findings were indicative of a retinoblastoma. The patient was enucleated and the diagnosis of retinoblastoma was confirmed. Intraocular surgery in young people with unknown retinoblastoma enhances the risk of metastasis development, orbital recurrence and death. Unexplained vitreous haemorrhage can obscure the view of a tumour but ultrasonic findings of a retinal mass calls for further imaging e.g. through MRI. The case illustrates the importance of excluding intraocular malignancy and advises a limited use of surgery in the initial examination of vitreous haemorrhage in young people.

Keywords: Late onset retinoblastoma, vitreous haemorrhage, vitrectomy, retinal tumour.