Death by Water: Precautionary Water Submersion for Intravitreal Injection of Retinoblastoma Eyes



Jasmine H Francis*, 1, Xiaoliang L Xu 2, Y. Pierre Gobin 3, Brian P Marr 1, 4, Scott E Brodie 5, David H Abramson 1, 4
1 Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
2 Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
3 Service of Interventional Neuroradiology, Departments of Neurosurgery, Neurology and Radiology, Weill Cornell Medical College of New York-Presbyterian Hospital, New York, NY, USA
4 Department of Ophthalmology, Weill Cornell Medical College of New York-Presbyterian Hospital, New York, NY, USA
5 Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA


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© Francis et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, 70 East 66th Street, New York, NY 10065, USA; Tel: (212) 744 1700; Fax: (212) 734 2553; E-mail: francij1@mskcc.org


Abstract

There is growing interest in intravitreal injections of chemotherapy for retinoblastoma. However, concerns for potential tumor seeding through the needle track has prompted the use of risk-reducing precautionary methods. Presented here is a novel technique, which can be easily replicated, requires minimal sophisticated equipment and with laboratory data supporting its concept. Sterile distilled water submersion for 3 minutes renders retinoblastoma cells nonviable and can be employed as a precautionary method following intravitreal injection in the technique described here.

Keywords: Cancer, chemotherapy, distilled water, fine needle aspiration, intravitreal injection, melphalan, retinoblastoma, water.