The Association Between Primary Open Angle Glaucoma and Clustered Components of Metabolic Syndrome

Seyed Ahmad Rasoulinejad 1, Ali Kasiri 2, Mahdi Montazeri 3, Negin Rashidi4, Maryam Montazeri*, 5, Mohammad Montazeri 6, Hesam Hedayati 2
1 Department of Ophthalmology, Babol University of Medical Sciences, Babol, Iran
2 Department of Ophthalmology, Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Cardiology, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Internal Medicine, Tehran University of Medical Sciences, Tehran, Iran
5 Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
6 Young Researchers Club, Islamic Azad University, Babol Branch, Babol, Iran

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© Rasoulinejad et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the (, which permits unrestricted, noncommercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Nemazee Hospital, Nemazee Sq., Shiraz, Iran; Tel: +98 711 6474270; Fax: +98 711 6474270; E-mail:


Purpose :

There is conflicting evidence whether components of metabolic syndrome (MetS) increase or decrease the risk of primary open-angle glaucoma (POAG). The aim of the present study was to determine the association between metabolic syndrome and primary open-angle glaucoma.

Methods :

A total of 200 participants comprising 100 controls and 100 patients with POAG documented by clinical tests and examined by an experienced ophthalmologist using standard ophthalmologic equipment were included in the study. MetS was defined and based on ATP III criteria and POAG was defined by the criteria of the International Society of Geographic and Epidemiological Ophthalmology (ISGEO). The data were entered into the SPSS software and analyzed.

Results :

The prevalence of MetS in the glaucoma group was 53% in comparison to 38% in the control group (p=0.037). MetS was associated with an increased odds ratio for an IOP higher than 21 mmHg (OR: 1.72; 95% CI 1.03-2.79; p=0.034). The mean IOP was 24.91±4.29 mmHg in the patients without MetS, and 27.23±4.81 mmHg in those with MetS (p=0.027). The mean values of CCT were 603.64±63.16 µm in MetS patients and 579.27±72.87 µm in controls (p=0.018).

Conclusion :

Data showed an increased prevalence of components of metabolic syndrome in patients with glaucoma. The mechanisms underlying these associations need to be established in future studies. Our results support the recommendation that patients with metabolic syndrome undergo regular ophthalmological exams to monitor for the onset or progression of glaucoma.

Keywords: Central corneal thickness, intraocular pressure, metabolic syndrome, open-angle glaucoma.