Coats’ Disease: Very Long-Term Outcome After Early Stage Conventional Treatment

Salvatore Perrone*, Alberto Rossetti, Patrick Sportiello, Pierfrancesco Mirabelli, Pierangela Cimatti, Daniele Doro
Department of Ophthalmology, University Hospital of Padua, Padua, Italy

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© Perrone et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at Dipartimento di Neuroscienze - Clinica Oculistica, Università di Padova, via Giustiniani 2, 35128, Padova, Italy; Tel: +390498212110, Fax: +390498755168; E-mail:



To report on the outcome of conventional therapy in patients with Coats’ disease.


Retrospective analysis of the charts of thirteen patients with Coats’ disease.


Mean age of 9 male (70%) and 4 female (30%) patients was 17.7 (range, 5-33) years; one female had bilateral disease. Eleven eyes with retinal telangiectasia and exudation were treated with argon laser photocoagulation alone or photocoagulation associated with cryotherapy; the mean follow up was 32.5 (range,17-41) years. In four eyes without foveal involvement (stage 2a) the mean presenting visual acuity (VA) remained at 0.8 or improved, whereas poor VA in seven stage 2b eyes deteriorated minimally over time. In one and two of the three eyes with total retinal detachment, phthisis or neovascular glaucoma ensued.


About three decades after conventional treatment of Coats’ disease stage 2a, treated eyes maintained good VA, and stage 2b eyes did not progress to advanced stages.

Keywords: Coats' disease, exudative retinopathy, neovascular glaucoma, retinal detachment, telangiectasia.