First Reported Case of Donor Related Candida Endophthalmitis after Descemet Membrane Endothelial Keratoplasty

Matthew Thompson1, *, David Carli2
1 Tower Clock Eye Center 1087 W Mason St. Green Bay, WI, 54303, USA
2 Medical Student Des Moines University, 3200 Grand Ave Des Moines, IA 50312, USA

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© 2017 Thompson and Carli.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Tower Clock Eye Center, 1087 W Mason St., Green Bay WI, 54303, USA; Tel: 920-499-3102; Fax: 920-499-9636; E-mail:



To report the first case of Candida donor to host transmission following descemet membrane endothelial keratoplasty (DMEK)


A retrospective case report.


A patient underwent uneventful DMEK. Following surgery the donor rim was culture positive for Candida. The patient developed fungal endophthalmitis that was treated medically with multiple injections of voriconazole and amphotericin. Medical treatment was unable to clear the infection and removal of the donor material was required. Following removal the infection subsided.


Candida interface keratitis and endophthalmitis can occur following DMEK and may be difficult to treat medically. Early removal of the donor material should be considered.

Keywords: Candida, candida albicans, candida glabrata, fungal keratitis, descemet stripping endothelial keratoplasty, DMEK, corneal donor rim contamination.