Collagen Cross- Linking for Paediatric Keratoconus

Georgios D. Panos1, *, Nikolaos Kozeis2, Miltiadis Balidis2, Marilita M. Moschos3, Farhad Hafezi4
1 Department of Ophthalmology, Ipswich Hospital NHS Trust, University of Cambridge, Ipswich, Suffolk, UK
2 Ophthalmica Institute, Thessaloniki, Central Macedonia, Greece
3 Department of Ophthalmology, School of Medicine, National and Kapodistrian University of Athens, Greece
4 ELZA Institute, Zurich, Switzerland; Faculty of Medicine, University of Geneva, Geneva, Switzerland; Faculty of Medicine, University of South California, California, USA

© 2017 Panos et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Eye Department, The Ipswich Hospital NHS Trust, Heath Road, IP4 5PD, Ipswich, Suffolk, UK, Tel: +44 (0) 1473 712233; Fax: +44 (0) 1473 703400; E-mails:;



Since the late 1990s corneal crosslinking (CXL) has been proposed as a new treatment option which can stop progression of keratoconus with promising results in adults.


Keratoconus presents a higher rate and faster progression in paediatric patients and for this reason prompt and effective treatment is essential. Due to its success in adult keratoconus patients, CXL has been recently applied to children in order to stop or slow progression of keratoconus in paediatric patients.


This article will present an update of the literature on the topic of CXL in this age group.
Keywords: Paediatric keratοcοnus, Cοllagen crοss- linking, Biometry, Cοrnea.