Genetics in Keratoconus – What is New?
Sarah Moussa*, Günther Grabner, Josef Ruckhofer, Marie Dietrich, Herbert Reitsamer
Identifiers and Pagination:Year: 2017
Issue: Suppl-1, M4
First Page: 201
Last Page: 210
Publisher Id: TOOPHTJ-11-201
Article History:Received Date: 21/01/2017
Revision Received Date: 01/04/2017
Acceptance Date: 14/06/2017
Electronic publication date: 31/07/2017
Collection year: 2017
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keratoconus is characterized as a bilateral, progressive, non-inflammatory thinning of the cornea resulting in blurred vision due to irregular astigmatism. Keratoconus has a multifactorial etiology, with multiple genetic and environmental components contributing to the disease pathophysiology. Several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease.
The review focuses on current knowledge of these genetic risk factors associated with keratoconus.