RESEARCH ARTICLE
The Effect of Vitamin E on Oxidative Stress Indicated by Serum Malondialdehyde in Insulin-dependent Type 2 Diabetes Mellitus Patients with Retinopathy
Irini P. Chatziralli1, *, George Theodossiadis1, Prodromos Dimitriadis2, Michail Charalambidis2, Antonios Agorastos2, Zisis Migkos2, Nikolaos Platogiannis2, Marilita M. Moschos3, Panagiotis Theodossiadis1, Petros Keryttopoulos2
Article Information
Identifiers and Pagination:
Year: 2017Volume: 11
First Page: 51
Last Page: 58
Publisher ID: TOOPHTJ-11-51
DOI: 10.2174/1874364101711010051
Article History:
Received Date: 09/12/2016Revision Received Date: 16/02/2017
Acceptance Date: 03/03/2017
Electronic publication date: 31/03/2017
Collection year: 2017
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background:
Several studies have focused on oxidative stress on diabetes mellitus (DM). Our purpose was to investigate the impact of oxidative stress on progression of diabetic retinopathy (DR) in insulin-dependent type 2 DM patients, measuring serum malondialdehyde (MDA), as well as to examine the effect of vitamin E on DR progression in the above-mentioned patients.
Methods:
Participants in the study were 282 insulin-dependent type 2 DM patients with DR. All participants underwent a thorough ophthalmological examination, so as to grade DR, along with serum MDA measurement. All participants received 300mg vitamin E daily for 3 months and were examined again. Serum MDA pre- and post-intake of Vitamin E was the main outcome.
Results:
Serum MDA was positively associated with DR stage, while there was a statistically significant difference pre- and post-intake of vitamin E in all DR stages. In a subgroup analysis of patients with proliferative DR, there was a significant difference at baseline between patients who have received prior laser photocoagulation and the treatment naïve patients, while after intake of vitamin E, no statistically significant difference was noticed.
Conclusion:
Oxidative stress has been found to play significant role in the pathogenesis and progression of DR, while vitamin E seems to reduce MDA levels and subsequent oxidative stress, suggesting that it might have protective role in DR progression.
