The Effect of Vitamin E on Oxidative Stress Indicated by Serum Malondialdehyde in Insulin-dependent Type 2 Diabetes Mellitus Patients with Retinopathy

Irini P. Chatziralli1, *, George Theodossiadis1, Prodromos Dimitriadis2, Michail Charalambidis2, Antonios Agorastos2, Zisis Migkos2, Nikolaos Platogiannis2, Marilita M. Moschos3, Panagiotis Theodossiadis1, Petros Keryttopoulos2
1 2nd Department of Ophthalmology, University of Athens, Athens, Greece
2 Department of Internal Medicine, General Hospital of Veroia, Veroia, Greece
3 1st Department of Ophthalmology, University of Athens, Athens, Greece

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© 2017 Chatziralli et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this authors at the Department of Ophthalmology, University of Athens, Athens, Greece, Department of Ophthalmology, Henry Dunant Hospital, Athens, Greece, Tel: 00306973046326, E-mail:



Several studies have focused on oxidative stress on diabetes mellitus (DM). Our purpose was to investigate the impact of oxidative stress on progression of diabetic retinopathy (DR) in insulin-dependent type 2 DM patients, measuring serum malondialdehyde (MDA), as well as to examine the effect of vitamin E on DR progression in the above-mentioned patients.


Participants in the study were 282 insulin-dependent type 2 DM patients with DR. All participants underwent a thorough ophthalmological examination, so as to grade DR, along with serum MDA measurement. All participants received 300mg vitamin E daily for 3 months and were examined again. Serum MDA pre- and post-intake of Vitamin E was the main outcome.


Serum MDA was positively associated with DR stage, while there was a statistically significant difference pre- and post-intake of vitamin E in all DR stages. In a subgroup analysis of patients with proliferative DR, there was a significant difference at baseline between patients who have received prior laser photocoagulation and the treatment naïve patients, while after intake of vitamin E, no statistically significant difference was noticed.


Oxidative stress has been found to play significant role in the pathogenesis and progression of DR, while vitamin E seems to reduce MDA levels and subsequent oxidative stress, suggesting that it might have protective role in DR progression.

Keywords: Oxidative stress, Diabetes mellitus, Malondialdehyde, Vitamin E.