RESEARCH ARTICLE
Dual Pathogenesis of Primary and Recurrent Pterygium: Immunohistochemical Proof
Doaa Ghorab1, Ahmed Helaly2, 3, *, Amani E. Badawi4
Article Information
Identifiers and Pagination:
Year: 2021Volume: 15
First Page: 229
Last Page: 235
Publisher ID: TOOPHTJ-15-229
DOI: 10.2174/1874364102115010229
Article History:
Received Date: 27/4/2021Revision Received Date: 15/7/2021
Acceptance Date: 27/7/2021
Electronic publication date: 19/11/2021
Collection year: 2021
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Introduction:
Pterygium is a common ophthalmic problem in the Middle East where exposures to dust and sun rays are risk factors. The condition is more prevalent in middle-aged males and can be considered as an aging process. The aim of this study is to test both the degenerative and the proliferative components of Pterygium by both reduced glutathione and topoisomerase one activity.
Methods:
The study applied immunohistochemistry staining for both reduced glutathione and topoisomerase 1.
Results:
The samples expressed positive glutathione staining in most primary Pterygium conditions and all secondary Pterygium. On the other hand, the topoisomerase 1 immunohistochemistry expressed focal activity in secondary conditions suggesting a progenitor cell role in the pathogenesis of Pterygium in conjunction with oxidative stress.
Conclusion:
Pterygium represents dual pathology with a proliferative component and a degenerative one that needs further studies. It is possible to use combination immunohistochemistry markers to predict the prognosis of Pterygium behavior.
