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Age-related Changes of the Corneal Endothelium in the Hispanic Elderly Population
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Gustavo Ortiz-Morales1 , #
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Nallely Morales-Mancillas1
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Jorge Luis Domene-Hickman2
Julio Hernández-Camarena1
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Denise Loya-García1
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Judith Zavala2
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Alejandro Rodriguez-García.1
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Authors Info & Affiliations
Abstract
Purpose:
To assess the corneal endothelial morphometry in healthy elderly Hispanic eyes.
Methods:
A retrospective, cross-sectional, observational, descriptive, and analytical study was designed to assess the central region of the corneal endothelium by specular microscopy. A total of 241 eyes from 125 patients were studied. All eyes included were from healthy patients 65 or older (mean: 74.56± 6.74), without ocular disease or surgeries.
Results:
The mean cell density (MCD) was 2198.92±493.43 cells/mm2. 125 (51.87%) eyes had polymegethism, with a mean coefficient of variation (CV) of 42.89 ± 9.16%. 148 (61.41%) eyes presented pleomorphism, with an average of 46.25 ± 7.13% hexagonal cells. The mean corneal thickness was 527.55±28.37 μm. A statistically significant difference between age groups was found for MCD and pachymetry (P<0.05). 41 eyes (17.01%) had cornea guttata.
Conclusion:
This study suggests that the elderly Hispanic population has a high prevalence of polymegethism, pleomorphism, and guttata. Surprisingly, the oldest age group (>85) had an above-average MCD, with lower rates of polymegethism and pleomorphism.
Trial Registration Number: #ARCC/ECH2019
Date of Registration: October 18, 2019
