Performance of a Silicone Hydrogel Daily Disposable Contact Lens among Wearers with Lens-related Dryness

William Reindel1, Robert Steffen1, Gary Mosehauer1, Jeffery Schafer1, Marjorie Rah1, *, Ayda Shahidi1, Howard Proskin2
1 Vision Care, Bausch & Lomb Incorporated, Rochester, NY, USA
2 Howard M. Proskin & Associates, Rochester, NY, USA

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© 2023 Reindel et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Vision Care, Bausch & Lomb Incorporated, Rochester, NY, USA; Tel: 1 585-413-6397; E-mail:



Addressing contact lens dryness continues to be a development goal of contact lens (CL) manufacturers.


The objective of this study is to evaluate the clinical performance of kalifilcon A, a daily disposable silicone hydrogel (SiHy) CL, in subjects that experience dryness with their habitual planned-replacement SiHy CLs relative to a non-dry subgroup.


A cohort of adapted planned-replacement SiHy CL wearers wore kalifilcon A lenses for at least 8 hours daily over two weeks. After one week of lens wear, subjects completed a survey regarding their lens wearing experience with respect to comfort and vision. Subsequently, subjects visited the clinics for the 2-week visit, during which the investigators completed a slit lamp exam and questionnaire regarding lens performance.


The evaluation included 180 subjects experiencing CL dryness with their habitual SiHy lenses and 213 subjects that did not. Both subgroups largely agreed with all comfort and vision attribute statements, and the dryness subgroup expressed higher levels of agreement with most comfort-related statements. Among habitual rewetting drop users, 73.9% in the dryness subgroup and 73.1% in the non-dry subgroup used drops less frequently while wearing kalifilcon A lenses. Investigators found no > Grade 2 slit-lamp findings, nor differences between subgroups. Neither subgroup showed a change in ratings between visits, except for a significantly higher proportion of improvers in the non-dry subgroup for upper lid tarsal conjunctival abnormalities.


The kalifilcon A lens performed well among habitual planned-replacement SiHy CLs wearers. Its unique chemistry can provide a more satisfying wear experience for SiHy lens wearers experiencing CL dryness.

Keywords: Homeostasis, TFOS DEWS II, Contact lens, Kalifilcon A, Dryness, Dry eye.