Evaluation of Inflammatory Parameters in Patients with Acute Retinal Necrosis

Acute retinal necrosis (ARN) is a vision-threatening viral uveitis. This study aimed to evaluate the clinical characteristics of patients with ARN and compare the blood gamma-glutamyl transferase (GGT)-to-lymphocyte count ratio (GLR) and neutrophil-to-lymphocyte ratio (NLR) between patients with ARN and healthy controls.

This is a retrospective case-control observational study. Twenty patients with ARN who were diagnosed in Beijing Chaoyang Hospital between July 2017 and October 2021 were enrolled in this study. Sex- and age-matched healthy individuals from the same period were classified as the control group. The disparities in albumin, prealbumin, GGT, NC, LC, NLR, mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), neutrophil-to-albumin ratio (NAR), and GLR between both groups were analyzed. The clinical features of patients with ARN were evaluated.

The median age of patients with ARN was 49.05 years. 15 (75%) were infected with varicella zoster virus (VZV), 1 (5%) was infected with herpes simplex virus (HSV), and 4 (20%) had no infection testing. Retinal detachment occurred in 6 patients (30%). Prealbumin (P=0.019) and NC (P=0.025) were significantly higher in male patients than in female patients, whereas other baseline data showed no significant differences between male and female patients (P>0.05). There were significant differences in the NC (P=0.001), NLR (P=0.017), and GLR (P<0.001).

This report indicated that these blood-derived markers may serve as auxiliary indicators of systemic inflammation in ARN.

The ARN group had significantly higher levels of NC (p=0.001), NLR (p=0.017), and GLR (p < 0.001) than those in the control group.