Autoimmune Retinopathy in Systemic Lupus Erythematosus: Histopathologic Features
Xiaoguang Cao1, Rachel J Bishop2, Farzin Forooghian2, Youngeun Cho1, Robert N Fariss3, Chi-Chao Chan*, 1
Identifiers and Pagination:Year: 2009
First Page: 20
Last Page: 25
Publisher ID: TOOPHTJ-3-20
Article History:Received Date: 26/1/2009
Revision Received Date: 5/3/2009
Acceptance Date: 18/3/2009
Electronic publication date: 28/4/2009
Collection year: 2009
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
The ocular pathology of autoimmune retinopathy is demonstrated in a 62-year-old female patient with systemic lupus erythematosus (SLE) who presented with typical clinical autoimmune retinopathy. Macroscopically, there were multiple depigmented lesions in the peripheral retina and choroid and scattered pigmentary bone-spickling at the equator and periphery. Microscopically, there were generalized loss of photoreceptors and thinning of the outer plexiform layer. Many peripheral retinal vessels were sclerotic and occluded, some surrounded by pigment granules and RPE cells. Cobblestone degeneration was prominent in the periphery. Macrophages were seen in the retina, particularly in areas of photoreceptor degeneration. Rare, scattered T- lymphocytes were present in the retina and choroid, while B-cells were notably absent. The optic nerve showed loss of axons and thickened septae. Serum autoantibodies against normal retinal nuclei were detected. These pathological changes represent both known SLE-associated ocular complications as well as possible features of autoimmune retinopathy secondary to SLE.