RESEARCH ARTICLE


Intracameral Recombinant Tissue Plasminogen Activator for Refractory Glaucoma Secondary to a Fungal Corneal Abscess



L. Jay Katz*, Oana Stirbu, Garth Willis, Parul Ichhpujani
Wills Eye Institute, 840 Walnut Street, Philadelphia, USA


Article Metrics

CrossRef Citations:
0
Total Statistics:

Full-Text HTML Views: 1170
Abstract HTML Views: 964
PDF Downloads: 301
Total Views/Downloads: 2435
Unique Statistics:

Full-Text HTML Views: 667
Abstract HTML Views: 616
PDF Downloads: 207
Total Views/Downloads: 1490



© Katzet al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Glaucoma service, Wills Eye Institute, 840 Walnut Street, Philadelphia, USA; Tel: 215-285-8148; Fax: 215- 928-3903; E-mail: ljk22222@aol.com


Abstract

We present a 78-year-old patient who developed refractory glaucoma following a fungal infection of the corneal incision after cataract extraction with posterior chamber intraocular lens implantation. An anterior chamber injection of 0.1 ml recombinant tissue plasminogen activator (25 mcg/0.1 mL) was performed to improve the trabecular meshwork outflow facility compromised secondary to fibrin blockade. The intraocular pressure dropped dramatically from 48 mmHg to 10 mmHg postoperatively, negating the need for glaucoma surgery.