The Special Electrophysiological Signs of Inherited Retinal Dystrophies
Elena Prokofyeva*, 1, 2, Eric Troeger1, Eberhart Zrenner1
Identifiers and Pagination:Year: 2012
First Page: 86
Last Page: 97
Publisher ID: TOOPHTJ-6-86
Article History:Received Date: 28/6/2012
Revision Received Date: 12/9/2012
Acceptance Date: 12/9/2012
Electronic publication date: 31/10/2012
Collection year: 2012
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The study aim was to analyze the electrophysiological signs of inherited retinal dystrophies (IRD). Full-field and multifocal (mf) electroretinography (ERG) was analysed in three groups: 21 normal subjects, 21 randomly selected IRD patients, and 21 patients randomly selected from each of eleven IRD groups. As a result, median, 5-95 and 25-75 interquantile intervals of each full-field and mfERG parameter were estimated for each of the above mentioned groups and compared using a Kruskal-Wallis test. Quantitative and qualitative criteria defined in this study will improve the precision of differential diagnosis, the detection of IRD severity, and the efficacy of treatment. The quantitative and qualitative characteristics of ERG values, established in this study, can be further applied to the creation of software that will allow the automatic classification of the recording into a specific disease and degree of severity.