Surgically Induced Corneal Astigmatism Following Intravitreal Ranibizumab Injection



Tolga Kocatürk *, 1, Erol Erkan 1, Sait Eğrilmez2, Harun Çakmak1, Sema O. Dündar1, Volkan Dayanir1
1 Department of Ophthalmology, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey
2 Department of Ophthalmology, Faculty of Medicine, Ege University, Izmir, Turkey
3 Hospital Pulau Pinang, Jalan Residensi, 10990 Georgetown, Pulau Pinang, Malaysia


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© Kocatürk et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Ophthalmology, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey; Tel: 00 90 533 344 41 11; Fax: 00 90 256 214 64 95; E-mail: tolgakocaturk@gmail.com


Abstract

Purpose :

To evaluate surgically induced astigmatism (SIA) after an intravitreal ranibizumab (IVR) injection.

Methods :

Fifty eight eyes of 58 patients who underwent IVR injection due to age-related macular degeneration (wet form) or macular edema were included in this study. Patients’ pre- and postoperative detailed ophthalmologic examinations were done and topographic keratometric values (K1, K2) were noted. Pre- and postoperative measurements were compared.

Results :

The mean preoperative astigmatism of 0.87 Diopters (D) was found to be 0.95 D, 0.75 D, 0.82 D and 0.78 D on the 1st day, 3rd day, 1st week and 1st month, respectively. After injection, absolute change in astigmatism was found to be 0.08 D, 0.12 D, 0.05 D and 0.09 D on the 1st day, 3rd day, 1st week and 1st month, respectively. The absolute change in astigmatism seemed to be insignificant in terms of refractive analysis, however; when we performed a vectorial analysis, which takes into account changes in the axis of astigmatism, the mean value of induced astigmatism were found to be 0.33±0.22 D, 0.32±0.29 D, 0.41±0.37 D, 0.46±0.32 D on the 1st day, 3rd day, 1st week and on 1st month, respectively.

Conclusion :

Intravitreal injection is a minimally invasive ophthalmologic procedure, however; it may still cause statistically significant induced astigmatism when evaluated from a vectorial point of view.

Keywords: Intraocular pressure, intravitreal injection, ranibizumab, surgically induced astigmatism, vectorial analysis.