RESEARCH ARTICLE
Visual Acuity, Contrast Sensitivity and Color Vision Three Years After Iodine-125 Brachytherapy for Choroidal and Ciliary Body Melanoma
Irena Tsui 1, Robert M Beardsley 1, Tara A McCannel 1, Scott C Oliver 2, Melissa W Chun 1, Steve P Lee 3, Phillip E Chow 3, Nzhde Agazaryan 3, Fei Yu 1, Bradley R Straatsma*, 1
Article Information
Identifiers and Pagination:
Year: 2015Volume: 9
First Page: 131
Last Page: 135
Publisher ID: TOOPHTJ-9-131
DOI: 10.2174/1874364101509010131
Article History:
Received Date: 13/2/2015Revision Received Date: 29/4/2015
Acceptance Date: 11/5/2015
Electronic publication date: 26/6/2015
Collection year: 2015

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Purpose :
To report visual acuity, contrast sensitivity and color vision prior to, 1 year after, 2 years after and 3 years after iodine-125 brachytherapy for choroidal and ciliary body melanoma (CCM).
Design :
Prospective interventional case series.
Participants :
Thirty-seven patients (37 eyes) with CCM.
Methods :
Patients had best-corrected Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity, Pelli-Robson contrast sensitivity and Hardy-Rand-Rittler color vision measurement; comprehensive ophthalmology examination; optical coherence tomography; and ultrasonography at baseline prior to, 1 year after, 2 years after and 3 years after I-125 brachytherapy.
Main Outcome Measures :
Visual acuity, contrast sensitivity and color vision prior to, 1 year after, 2 years after and 3 years after brachytherapy.
Results :
Nineteen (19) men and 18 women with mean age of 58 years (SD 13, range 30-78) prior to, 1 year after, 2 years after and 3 years after brachytherapy had mean best-corrected visual acuity of 77 letters (20/32), 65 letters (20/50), 56 letters (20/80) and 47 letters (20/125); contrast sensitivity of 30, 26, 22 and 19 letters; color vision of 26, 20, 17 and 14 test figures, respectively. Decrease in visual acuity, contrast sensitivity and color vision was statistically significant from baseline at 1 year, 2 years, and 3 years after brachytherapy. Decreased acuity at 3 years was associated with mid-choroid and macula melanoma location, ≥ 4.1 mm melanoma height, radiation maculopathy and radiation optic neuropathy.
Conclusion :
1, 2 and 3 years after brachytherapy, eyes with CCM had significantly decreased visual acuity, contrast sensitivity and color vision.