HRT for the Diagnosis and Detection of Glaucoma Progression

Jessica S Maslin 1, Kaweh Mansouri 2, Syril K Dorairaj*, 3
1 Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA
2 Division of Ophthalmology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland
3 Department of Ophthalmology, Mayo Clinic, Jacksonville, FL, USA

Article Metrics

CrossRef Citations:
Total Statistics:

Full-Text HTML Views: 5829
Abstract HTML Views: 1837
PDF Downloads: 891
Total Views/Downloads: 8557
Unique Statistics:

Full-Text HTML Views: 2944
Abstract HTML Views: 1092
PDF Downloads: 584
Total Views/Downloads: 4620

Creative Commons License
© Maslin et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA; Tel: 904-953-2377; Fax: 904-953-7040; E-mail:


Confocal scanning laser ophthalmoscopy through the Heidelberg Retina Tomograph (HRT) provides a rapid, safe, noncontact, and noninvasive imaging of the optic disc in three-dimensions, and provides precise detailed information about the optic disc beyond that which the clinical exam can measure. The HRT I was developed for research purposes only and was not used clinically. The HRT II was developed to be user-friendly, more rapid, and was used as an adjunct to clinical examination in the detection and progression of glaucoma. One of the main pitfalls of the HRT II was that it was operator-dependent. The HRT III was developed to be operator-independent. Initially the Moorsfield Regression Analysis provided the analysis of the stereometric optic disc parameters. The Glaucoma Probability Score, given its ease of use, operator-independence, and rapidity of use, soon gained popularity. Numerous studies have compared these two methods of analysis, with the conclusion that the Glaucoma Probability Score provides a higher sensitivity and a lower specificity than the Moorsfield Regression Analysis, which may indicate that it has potential as a screening test for glaucoma. However, there is no consensus on the use of the Glaucoma Probability Score as a screening test for glaucoma. While HRT data may be useful as a clinical adjunct in the screening and diagnosis of glaucoma, it should ultimately only be used to support clinical examination.

Keywords: Glaucoma, Heidelberg retina tomograph, retinal nerve fiber layer, topographic change analysis.