Spectral-Domain Optical Coherence Tomography for Glaucoma Diagnosis

Carolina P.B Gracitelli 1, 2, Ricardo Y Abe 1, 3, Felipe A Medeiros*, 1
1 Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California, USA
2 Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
3 Department of Ophthalmology, University of Campinas, Campinas, Brazil

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© Gracitelli et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Hamilton Glaucoma Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0946, USA; Fax: 858-822-0615; E-mail:


Identification of structural damage to the optic nerve and retinal nerve fiber layer (RNFL) is an essential component of diagnosis and management of glaucoma. The introduction of spectral-domain OCT (SD-OCT) has allowed objective quantification of damage to these structures with unprecedented resolution. In addition, recent attention has been directed towards imaging the macular area for quantifying loss of neural tissue caused by the disease. Many studies have evaluated and compared the diagnostic accuracies of a variety of parameters that can be obtained from imaging these areas of the ocular fundus. In this article, we critically review the existing literature evaluating the diagnostic accuracy of SD-OCT in glaucoma and we discuss issues related to how SD-OCT results should be incorporated into clinical practice.

Keywords: Glaucoma, imaging instruments, optical coherence tomography, retina nerve fiber layer thickness, spectral domain.